Shaggy and Scooby’s vacation in Hawaii is interrupted by a ghostly witch doctor, who warns the tourists and natives they are on the sacred grounds of the island god Mano Tiki Tia and to stay away from the cursed village. Later, the gang’s guide John Simms goes missing, so it is up to the gang to search for him in the supposedly cursed village, where they eventually run into the witch doctor and the giant living statue of Mano Tiki Tia.