The gang is attacked by a hi-tech assassin called the Obliteratrix, who tells them that they all have to die. This leads the gang to investigate the mystery of the Cursed Treasure further with the assistance of Professor H.P. Hatecraft (who suspects his rival Regina Wentworth to be the Obliteratrix). Along the way, they discover the fate of the original Mystery Incorporated. Angel traps the Obliteratrix, revealed to be Alice May, who was acting on orders from Mr. E. Unknown to the gang, a mysterious creature called “The Freak of Crystal Cove” watches them from the shadows, saying that in the end, the curse will end with them.